摘要 One of the striking features of many eukaryotes i

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• 類型：已發表論文
• 日期：2016

摘要

One of the striking features of many eukaryotes is the apparent amount of redundancy in coding and non-coding elements of their 基因組s. Despite the possible 演化ary advantages, there are fewer examples of redundant sequences in viral 基因組s, particularly those with RNA 基因組s. The factors constraining the maintenance of redundant sequences in present-day RNA 病毒 基因組s are not well known. Here, we use Tobacco etch 病毒, a plant RNA 病毒, to investigate the stability of 遺傳ally redundant sequences by generating 病毒es with potentially beneficial gene duplications. Subsequently, we tested the viability of these 病毒es and performed experimental 演化. We found that all gene duplication events resulted in a loss of viability or in a significant reduction in viral fitness. Moreover, upon analyzing the 基因組s of the ev

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