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原文連結
論文資訊
- 類型：已發表論文
- 日期：2016-03-18
摘要
The influence of positive selection sweeps in human 演化 is increasingly debated, although our ability to detect them is hampered by inherent uncertainties in the timing of past events. Ancient 基因組s provide snapshots of allele frequencies in the past and can help address this question. We combine modern and ancient genomic data in a simple statistic (DAnc) to time allele frequency changes, and investigate the role of drift and 適應 in 族群 differentiation. Only 30% of the most strongly differentiated alleles between Africans and Eurasians changed in frequency during the colonization of Eurasia, but in Europe these alleles are enriched in genic and putatively functional alleles to an extent only compatible with local 適應. Adaptive alleles-especially those associated with pigmentation-are mostly of
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