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原文連結
論文資訊
- 類型：已發表論文
- 日期：2016-04-01
摘要
West Nile 病毒 (WNV) is an emerging pathogen that has decimated bird 族群s and caused severe outbreaks of viral encephalitis in humans. Currently, little is known about the within-host viral kinetics of WNV during infection. We developed 數學 models to describe viral replication, spread and host 免疫 response in wild-type and immunocompromised mice. Our approach fits a target cell-limited model to viremia data from immunocompromised knockout mice and an adaptive 免疫 response model to data from wild-type mice. Using this approach, we first estimate parameters governing viral production and viral spread in the host using simple models without 免疫 responses. We then use these parameters in a more complex 免疫 response model to characterize the dynamics of the humoral 免疫 response. Despite substantial unce
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