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原文連結
論文資訊
- 類型：已發表論文
- 日期：2016-04-22
摘要
A genotype 網絡 is a graph in which vertices represent genotypes that have the same phenotype. Edges connect vertices if their corresponding genotypes differ in a single small 突變. Genotype 網絡s are used to study the organization of genotype spaces. They have shed light on the relationship between robustness and evolvability in 生物 systems as different as RNA macromolecules and transcriptional regulatory circuits. Despite the importance of genotype 網絡s, no tool exists for their automatic construction, analysis and visualization. Here we fill this gap by presenting the Genonets Server, a tool that provides the following features: (i) the construction of genotype 網絡s for categorical and univariate phenotypes from DNA, RNA, amino acid or binary sequences; (ii) analyses of genotype 網絡 topology and
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