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原文連結
論文資訊
- 類型：已發表論文
- 日期：2016-07-19
摘要
The 多樣性 of long non-coding RNAs (lncRNAs) in the human transcriptome is in stark contrast to the sparse exploration of their functions concomitant with their conservation and 演化. The pervasive transcription of the largely non-coding human 基因組 makes the 演化ary age and conservation patterns of lncRNAs to a topic of interest. Yet it is a fairly unexplored field and not that easy to determine as for 蛋白質-coding genes. Although there are a few experimentally studied cases, which are conserved at the sequence level, most lncRNAs exhibit weak or untraceable primary sequence conservation. Recent studies shed light on the inter物種 conservation of secondary structures among lncRNA homologs by using diverse 計算 methods. This highlights the importance of structure on functionality of lncRNAs as opposed to
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