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原文連結
論文資訊
- 類型：已發表論文
- 日期：2016-07-21
摘要
Changing environments pose a challenge to living organisms. Cells need to gather and process incoming 資訊, adapting to changes in predictable ways. This requires in particular the presence of memory, which allows different internal states to be stored. 生物 memory can be stored by switches that retain 資訊 on past and present events. Synthetic biologists have implemented a number of memory devices for 生物 applications, mostly in single cells. It has been shown that the use of multicellular consortia provides interesting advantages to implement 生物 circuits. Here we show how to build a synthetic 生物 memory switch using an eukaryotic consortium. We engineered yeast cells that can communicate and retain memory of changes in the extracellular environment. These cells were able to produce and secrete a
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