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原文連結
論文資訊
- 類型：已發表論文
- 日期：2016-07-26
摘要
The human microbiome plays an important and increasingly recognized role in human health. Studies of the microbiome typically use targeted sequencing of the I 6S rRNA gene, whole meta基因組 shotgun sequencing, or other meta-omic technologies to characterize the microbiome's composition, activity, and dynamics. Processing, analyzing, and interpreting these data involve numerous 計算 tools that aim to filter, cluster, annotate, and quantify the obtained data and ultimately provide an accurate and interpretable profile of the micro biome's taxonomy, functional capacity, and behavior. These tools, however, are often limited in resolution and accuracy and may fail to capture many 生物ly and clinically relevant microbiome features, such as strain-level variation or nuanced functional response to pertur
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