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原文連結
論文資訊
- 類型：已發表論文
- 日期：2016-10-06
摘要
The dynamics of heterogeneous tumor cell 族群s competing with healthy cells is an important topic in 癌症 research with deep implications in biomedicine. Multitude of theoretical and 計算 models have addressed this issue, especially focusing on the nature of the transitions governing tumor clearance as some relevant model parameters are tuned. In this contribution, we analyze a 數學 model of unstable tumor progression using the quasi物種 framework. Our aim is to define a minimal model incorporating the dynamics of competition between healthy cells and a heterogeneous 族群 of 癌症 cell phenotypes involving changes in replication-related genes (i.e., proto-oncogenes and tumor suppressor genes), in genes responsible for genomic stability, and in house-keeping genes. Such 突變s or loss of genes result into di
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