本頁只刊出中文翻譯與中文說明；英文原文請見下方原文連結。
原文連結
論文資訊
- 類型：已發表論文
- 日期：2016-11-23
摘要
Bivalent (poised or paused) chromatin comprises activating and repressing histone modifications at the same location. This combination of epi遺傳 marks at promoter or enhancer regions keeps genes expressed at low levels but poised for rapid activation. Typically, DNA at bivalent promoters is only lowly methylated in normal cells, but frequently shows elevated methylation levels in 癌症 samples. Here, we developed a universal classifier built from chromatin data that can identify 癌症 samples solely from hypermethylation of bivalent chromatin. Tested on over 7,000 DNA methylation data sets from several 癌症 types, it reaches an AUC of 0.92. Although higher levels of DNA methylation are often associated with transcriptional silencing, counter-intuitive positive 統計 dependencies between DNA methylatio
※ 此為已發表論文，全文需透過期刊付費取得