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原文連結
論文資訊
- 類型：已發表論文
- 日期：2016-12-01
摘要
Understanding how multiple stressors interact is needed to predict the dynamical outcomes of diverse 生物 systems, ranging from drug-resistant pathogens that are combated and treated with combination drug therapies to ecosystems impacted by environmental toxicants or dist城市ces. Nevertheless, extensive studies of higher-order (more than two component) interactions have been lacking. Here, we conduct experiments using 20 three-drug combinations and their effects on the 細菌l growth of Escherichia coli. We report our measurements of growth rates in single, pairwise and triple-drug combinations. To uncover emergent interactions, we derive a simple framework to calculate expectations for three-way interactions based on the measured impact of each individual stressor and of each pairwise interaction
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