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原文連結
論文資訊
- 類型：已發表論文
- 日期：2016-12-23
摘要
Most disorders are caused by a combination of multiple 遺傳 and/or environmental factors. If two 疾病s are caused by the same molecular mechanism, they tend to co-occur in patients. Here we provide a quantitative method to disentangle how much 遺傳 or environmental risk factors contribute to the pathogenesis of 358 individual 疾病s, respectively. We pool data on 遺傳, pathway-based, and toxicogenomic 疾病-causing mechanisms with 疾病 co-occurrence data obtained from almost two million patients. From this data we construct a multiplex 網絡 where nodes represent disorders that are connected by links that either represent phenotypic comorbidity of the patients or the involvement of a certain molecular mechanism. From the similarity of phenotypic and mechanism-based 網絡s for each disorder we derive measure tha
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