摘要 Comparative analyses of the human microbiome have

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• 類型：已發表論文
• 日期：2017-01-19

摘要

Comparative analyses of the human microbiome have identified both taxonomic and functional shifts that are associated with numerous 疾病s. To date, however, microbiome taxonomy and function have mostly been studied independently and the taxonomic drivers of functional imbalances have not been systematically identified. Here, we present FishTaco, an analytical and 計算 framework that integrates taxonomic and functional comparative analyses to accurately quantify taxon-level contributions to 疾病-associated functional shifts. Applying FishTaco to several large-scale metagenomic cohorts, we show that shifts in the microbiome's functional capacity can be traced back to specific taxa. Furthermore, the set of taxa driving functional shifts and their contribution levels vary markedly between functions.

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