本頁只刊出中文翻譯與中文說明；英文原文請見下方原文連結。
原文連結
論文資訊
- 類型：已發表論文
- 日期：2017-02-27
摘要
Women in North America have a one in eight lifetime risk of developing breast 癌症 (BC), and a significant proportion of these individuals will develop recurrent BC and will eventually succumb to the 疾病. Metastatic, therapy-resistant BC cells are refractory to cell death induced by multiple stresses. Here, we document that the vitamin D receptor (VDR) acts as a master transcriptional regulator of autophagy. Activation of the VDR by vitamin D induces autophagy and an autophagic transcriptional signature in BC cells that correlates with increased survival in patients; strikingly, this signature is present in the normal mammary gland and is progressively lost in patients with metastatic BC. A number of 流行病學ological studies have shown that sufficient vitamin D serum levels might be protective ag
※ 此為已發表論文，全文需透過期刊付費取得