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原文連結
論文資訊
- 類型：已發表論文
- 日期：2017-05-06
摘要
Background: In drug-drug interactions, there are surprising cases in which the growth inhibition of 細菌 by a single 抗生素 decreases when a second 抗生素 is added. These interactions are termed suppressive and have been argued to have the potential to limit the 演化 of resistance. Nevertheless, little attention has been given to suppressive interactions because clinical studies typically search for increases in killing efficiency and because suppressive interactions are believed to be rare based on pairwise studies. Results: Here, we quantify the effects of single-, double-, and triple-drug combinations from a set of 14 抗生素s and 3 細菌 strains, totaling 364 unique three-drug combinations per 細菌 strain. We find that increasing the number of drugs can increase the prevalence of suppressive interactions
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