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原文連結
論文資訊
- 類型：已發表論文
- 日期：2017-08-01
摘要
An 演化ary constraint is a bias or limitation in phenotypic variation that a 生物 system produces. We know examples of such constraints, but we have no systematic understanding about their extent and causes for any one 生物 system. We here study 代謝s, genomically encoded complex 網絡s of enzyme-catalyzed biochemical reactions, and the constraints they experience in bringing forth novel phenotypes that allow survival on novel carbon sources. Our 計算 approach does not limit us to analyzing constrained variation in any one organism, but allows us to quantify constraints experienced by any 代謝. Specifically, we study 代謝s that are viable on one of 50 different carbon sources, and quantify how readily alterations of their chemical reactions create the ability to survive on a novel carbon source. We find th
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