聖塔非研究所

摘要 Background: Genomic DNA frequently undergoes rear

2017-08-23 · 已發表論文 · 更新 2026/08/30 下午12:48

摘要 Background: Genomic DNA frequently undergoes rearrangement of the gene order that can be localized by comparing the two DNA sequences. In mitochondrial 基因組s different mechanisms are likel…

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  • 類型:已發表論文
  • 日期:2017-08-23

摘要

Background: Genomic DNA frequently undergoes rearrangement of the gene order that can be localized by comparing the two DNA sequences. In mitochondrial 基因組s different mechanisms are likely at work, at least some of which involve the duplication of sequence around the location of the apparent breakpoints. We hypothesize that these different mechanisms of 基因組 rearrangement leave distinctive sequence footprints. In order to study such effects it is important to locate the breakpoint positions with precision. Results: We define a partially local sequence alignment problem that assumes that following a rearrangement of a sequence F, two fragments L, and R are produced that may exactly fit together to match F, leave a gap of deleted DNA between L and R, or overlap with each other. We show that t

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