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原文連結
論文資訊
- 類型：已發表論文
- 日期：2017-09-07
摘要
Many HIV-1-infected patients evolve broadly neutralizing antibodies (bnAbs). This 演化ary process typically takes several years and is poorly understood as selection taking place in germinal centers occurs on the basis of antibody affinity. B cells with the highest-affinity receptors tend to acquire the most antigen from the follicular dendritic cell (FDC) 網絡 and present the highest density of cognate peptides to follicular helper T (Tfh) cells, which provide survival signals to the B cell. bnAbs are therefore expected to evolve only when the B cell lineage evolving breadth is consistently capturing and presenting more peptides to Tfh cells than other lineages of more specific B cells. Here we develop 數學 models of Tfh cells in germinal centers to explicitly define the mechanisms of selection
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