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原文連結
論文資訊
- 類型：已發表論文
- 日期：2017-10-01
摘要
Background: The binding of small ligands to RNA elements can cause substantial changes in the RNA structure. This constitutes an important, fast-acting mechanism of ligand-controlled transcriptional and translational gene regulation implemented by a wide variety of riboswitches. The associated refolding processes often cannot be explained by 熱力學 effects alone. Instead, they are governed by the kinetics of RNA folding. While the 計算 analysis of RNA folding can make use of well-established models of the 熱力學s of RNA structures formation, RNA-RNA interaction, and RNA-ligand interaction, kinetic effects pose fundamentally more challenging problems due to the enormous size of the conformation space. The analysis of the combined process of ligand binding and structure formation even for small RNAs
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