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原文連結
論文資訊
- 類型：已發表論文
- 日期：2017-10-12
摘要
Effector T cell migration through tissues can enable control of infection or mediate inflammatory damage. Nevertheless, the molecular mechanisms that regulate migration of effector T cells within the interstitial space of inflamed lungs are incompletely understood. Here, we show T cell migration in a mouse model of acute lung injury with two-photon imaging of intact lung tissue. 計算 analysis indicates that T cells migrate with an intermittent mode, switching between confined and almost straight migration, guided by lung-associated vasculature. Rho-associated 蛋白質 kinase (ROCK) is required for both high-speed migration and straight motion. By contrast, inhibition of Gai signaling with pertussis toxin affects speed but not the intermittent migration of lung-infiltrating T cells. 計算 modeling sh
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