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原文連結
論文資訊
- 類型：已發表論文
- 日期：2017-12-19
摘要
Clusters of paralogous genes such as the famous HOX cluster of developmental transcription factors tend to evolve by stepwise duplication of its members, often involving unequal crossing over. Gene conversion and possibly other mechanisms of concerted 演化 further obfuscate the 系統發育 relationships. As a consequence, it is very difficult or even impossible to disentangle the detailed history of gene duplications in gene clusters. In this contribution we show that the expansion of gene clusters by unequal crossing over as proposed by Walter Gehring leads to distinctive patterns of 遺傳 distances, namely a subclass of circular split systems. Furthermore, when the gene cluster was left undisturbed by 基因組 rearrangements, the shortest Hamiltonian paths with respect to 遺傳 distances coincide with the g
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