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原文連結
論文資訊
- 類型：已發表論文
- 日期：2018
摘要
Robustness and evolvability are the main properties that account for the stability and accessibility of phenotypes. They have been studied in a number of 計算 genotype-phenotype maps. In this paper, we study a metabolic genotype-phenotype map defined in toyLIFE, a multilevel 計算 model that represents a simplified cellular biology. toyLIFE includes several levels of phenotypic expression, from 蛋白質s to regulatory 網絡s to 代謝. Our results show that toyLIFE shares many similarities with other seemingly unrelated 計算 genotype-phenotype maps. Thus, toyLIFE shows a high degeneracy in the mapping from genotypes to phenotypes, as well as a highly skewed distribution of phenotypic abundances. The neutral 網絡s associated with abundant phenotypes are highly navigable, and common phenotypes are close to each
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