摘要 抗生素s select for resistant 細菌 whose existence and

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論文資訊

• 類型：已發表論文
• 日期：2018

摘要

抗生素s select for resistant 細菌 whose existence and 湧現 is more likely in 族群s with high phenotypic and 遺傳 多樣性. Identifying the mechanisms that generate this 多樣性 can thus have clinical consequences for drug-resistant pathogens. We show here that intermediate levels of 抗生素s are associated with higher levels of phenotypic 多樣性 in size of colony forming units (cfus), within a single 細菌l 族群. We examine experimentally thousands of 族群s of 細菌 subjected to different dist城市ce levels that are created by varying 抗生素 concentrations. Based on colony sizes, we find that intermediate levels of 抗生素s always result in the highest phenotypic variation of this trait. This result is supported across 細菌l densities and in the presence of three different 抗生素s with two different mechanisms of action. Our results suggest

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