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原文連結
論文資訊
- 類型：已發表論文
- 日期：2018-03-01
摘要
Invadopodia are membrane protrusions dynamically assembled by invasive 癌症 cells in contact with the extracellular matrix (ECM). Invadopodia are enriched by the structural 蛋白質s actin and cortactin as well as metalloproteases such as MT1-MMP, whose function is to degrade the surrounding ECM. During metastasis, invadopodia are necessary for 癌症 cell intravasation and extravasation. Although signaling pathways involved in the assembly and function of invadopodia are well studied, few studies address invadopodia dynamics and how the cell-ECM interactions contribute to cell invasion. Using iterative analysis based on time-lapse microscopy and 數學 modeling of invasive 癌症 cells, we found that cells oscillate between invadopodia presence and cell stasis-termed the "invadopodia state"-and invadopodia
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