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原文連結
論文資訊
- 類型：已發表論文
- 日期：2018-03-01
摘要
The concept of niche partitioning has received considerable theoretical attention at the interface of 生態學 and 演化 of infectious 疾病s. Strain theory postulates that pathogen 族群s can be structured into distinct nonoverlapping strains by frequency-dependent selection in response to intraspecific competition for host 免疫 space. The malaria parasite Plasmodium falciparum presents an opportunity to investigate this phenomenon in nature, under conditions of high recombination rate and extensive antigenic 多樣性. The parasite's major blood-stage antigen, PfEMP1, is encoded by the hyperdiverse var genes. With a dataset that includes thousands of var DBL sequence types sampled from asymptomatic cases within an area of high endemicity in Ghana, we address how var 多樣性 is distributed within isolates and comp
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