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論文資訊
- 類型：已發表論文
- 日期：2018-04-11
摘要
Background: Heterotrimeric G 蛋白質s are fundamental signaling 蛋白質s composed of three subunits, G alpha and a G beta gamma dimer. The role of Ga as a molecular switch is critical for transmitting and amplifying intracellular signaling cascades initiated by an activated G 蛋白質 Coupled Receptor (GPCR). Despite their biochemical and therapeutic importance, the study of G 蛋白質 演化 has been limited to the scope of a few model organisms. Furthermore, of the five primary Ga subfamilies, the underlying gene structure of only two families has been thoroughly investigated outside of Mammalia 演化. Therefore our understanding of Ga 湧現 and 演化 across phylogeny remains incomplete. Results: We have 計算ly identified the presence and absence of every Ga gene (GNA-) across all major branches of Deuterostomia and eva
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