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原文連結
論文資訊
- 類型：已發表論文
- 日期：2018-05-01
摘要
Pathogens compete for hosts through patterns of cross-protection conferred by 免疫 responses to antigens. In Plasmodium falciparum malaria, the var multigene family encoding for the major blood-stage antigen PfEMP1 has evolved enormous 遺傳 多樣性 through ectopic recombination and 突變. With 50-60 var genes per 基因組, it is unclear whether 免疫 selection can act as a dominant force in structuring var repertoires of local 族群s. The combinatorial complexity of the var system remains beyond the reach of existing strain theory and previous evidence for non-random structure cannot demonstrate 免疫 selection without comparison with neutral models. We develop two neutral models that encompass malaria 流行病學 but exclude competitive interactions between parasites. These models, combined with 網絡s of 遺傳 similarity, re
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