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原文連結
論文資訊
- 類型：已發表論文
- 日期：2018-06-13
摘要
A challenge in studying diverse multi-copy gene families is deciphering distinct functional types within immense sequence variation. Functional changes can in some cases be tracked through the 演化ary history of a gene family; however 系統發育 approaches are not possible in cases where gene families diversify primarily by recombination. We take a 網絡 theoretical approach to functionally classify the highly recombining var antigenic gene family of the malaria parasite Plasmodium falciparum. We sample var DBLa sequence types from a local 族群 in Ghana, and classify 9,276 of these variants into just 48 functional types. Our approach is to first decompose each sequence type into its constituent, recombining parts; we then use a 隨機 block model to identify functional groups among the parts; finally, we c
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