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原文連結
論文資訊
- 類型：已發表論文
- 日期：2018-07-09
摘要
RNA 病毒es exist as a 遺傳ally diverse quasi物種 with extraordinary ability to adapt to abrupt changes in the host environment. However, the molecular mechanisms that contribute to their rapid 適應 and persistence in vivo are not well studied. Here, we probe hepatitis C 病毒 (HCV) persistence by analyzing clinical samples taken from subjects who were treated with a second-generation HCV protease inhibitor. Frequent longitudinal viral load determinations and large-scale single-基因組 sequence analyses revealed rapid antiviral resistance development, and surprisingly, dynamic turnover of dominant drug-resistant mutant 族群s long after treatment cessation. We fitted 數學 models to both the viral load and the viral sequencing data, and the results provided strong support for the critical roles that superinfect
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