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原文連結
論文資訊
- 類型：已發表論文
- 日期：2018-07-26
摘要
The telomerase RNA in yeasts is large, usually >1000 nt, and contains functional elements that have been extensively studied experimentally in several disparate 物種. Nevertheless, they are very difficult to detect by homology-based methods and so far have escaped annotation in the majority of the 基因組s of Saccharomycotina. This is a consequence of sequences that evolve rapidly at nucleotide level, are subject to large variations in size, and are highly plastic with respect to their secondary structures. Here, we report on a survey that was aimed at closing this gap in RNA annotation. Despite considerable efforts and the combination of a variety of different methods, it was only partially successful. While 27 new telomerase RNAs were identified, we had to restrict our efforts to the subgroup
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