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原文連結
論文資訊
- 類型：已發表論文
- 日期：2018-07-26
摘要
T cells play a vital role in eliminating pathogenic infections. To activate, naive T cells search lymph nodes (LNs) for dendritic cells (DCs). Positioning and movement of T cells in LNs is influenced by chemokines including CCL21 as well as multiple cell types and structures in the LNs. Previous studies have suggested that T cell positioning facilitates DC colocalization leading to T:DC interaction. Despite the influence chemical signals, cells, and structures can have on naive T cell positioning, relatively few studies have used quantitative measures to directly compare T cell interactions with key cell types. Here, we use Pearson correlation coefficient (PCC) and normalized mutual 資訊 (NMI) to quantify the extent to which naive T cells spatially associate with DCs, fibroblastic reticular
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