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原文連結
論文資訊
- 類型：已發表論文
- 日期：2019
摘要
Environmental factors like temperature, pressure, and pH partly shaped the 演化 of life. As life progressed, new stressors (e.g., poisons and 抗生素s) arose as part of an arms race among organisms. Here we ask if cells co-opted existing mechanisms to respond to new stressors, or whether new responses evolved de novo. We use a 網絡-clustering approach based purely on phenotypic growth measurements and interactions among the effects of stressors on 族群 growth. We apply this method to two types of stressors-temperature and 抗生素s-to discover the extent to which their cellular responses overlap in Escherichia coli. Our clustering reveals that responses to low and high temperatures are clearly separated, and each is grouped with responses to 抗生素s that have similar effects to cold or heat, respectively. A
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