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原文連結
論文資訊
- 類型：已發表論文
- 日期：2019
摘要
Predicting 演化ary change poses numerous challenges. Here we take advantage of the model bacterium Pseudomonas fluorescens in which the genotype-to-phenotype map determining 演化 of the adaptive 'wrinkly spreader' (WS) type is known. We present 數學 descriptions of three necessary regulatory pathways and use these to predict both the rate at which each 突變al route is used and the expected 突變al targets. To test predictions, 突變 rates and targets were determined for each pathway. Unanticipated 突變al hotspots caused experimental observations to depart from predictions but additional data led to refined models. A mismatch was observed between the spectra of WS-causing 突變s obtained with and without selection due to low fitness of previously undetected WS-causing 突變s. Our findings contribute toward the d
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