本頁只刊出中文翻譯與中文說明；英文原文請見下方原文連結。
原文連結
論文資訊
- 類型：已發表論文
- 日期：2019-12-12
摘要
In 細菌, 演化 of resistance to one 抗生素 is frequently associated with increased resistance (cross-resistance) or increased susceptibility (collateral sensitivity) to other 抗生素s. Cross-resistance and collateral sensitivity are typically evaluated at the minimum inhibitory concentration (MIC). However, these susceptibility changes are not well characterized with respect to the mutant prevention concentration (MPC), the 抗生素 concentration that prevents a single-step 突變 from occurring. We measured the MIC and the MPC for Staphylococcus epidermidis and 14 single-drug resistant strains against seven 抗生素s. We found that the MIC and the MPC were positively correlated but that this correlation weakened if cross-resistance did not evolve. If any type of resistance did evolve, the range of concentrations b
※ 此為已發表論文，全文需透過期刊付費取得