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原文連結
論文資訊
- 類型：已發表論文
- 日期：2020-03-10
摘要
The two most fundamental processes describing change in biology, development, and 演化, occur over drastically different timescales. Development involves temporal sequences of cell states controlled by hierarchies of regulatory structures. It occurs over the lifetime of a single individual and is associated with gene expression level change of a given genotype. 演化, by contrast, entails genotypic change through 突變, the acquisition/loss of genes and changes in the 網絡 topology of interactions among genes. It involves the 湧現 of new, environmentally selected phenotypes over the lifetimes of many individuals. We start by reviewing the most limiting aspects of the theoretical modeling of gene regulatory 網絡s (GRNs) which prevent the study of both timescales in a common, 數學 語言. We then consider the s
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