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原文連結
論文資訊
- 類型：已發表論文
- 日期：2020-04-09
摘要
Background Many of the commonly used methods for orthology detection start from mutually most similar pairs of genes (reciprocal best hits) as an approximation for 演化ary most closely related pairs of genes (reciprocal best matches). This approximation of best matches by best hits becomes exact for ultrametric dissimilarities, i.e., under the Molecular Clock Hypothesis. It fails, however, whenever there are large lineage specific rate variations among paralogous genes. In practice, this introduces a high level of noise into the input data for best-hit-based orthology detection methods. Results If additive distances between genes are known, then 演化ary most closely related pairs can be identified by considering certain quartets of genes provided that in each quartet the outgroup relative to t
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