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原文連結
論文資訊
- 類型：已發表論文
- 日期：2020-04-15
摘要
Ovarian 癌症 has one of the highest deaths to incidence ratios across all 癌症s. Initial chemotherapy is typically effective, but most patients will develop chemo-resistant 疾病. Mechanisms driving clinical chemo-response and -resistance in ovarian 癌症 are not well understood. However, achieving optimal surgical cytoreduction improves survival, and cytoreduction is improved by neoadjuvant platinum/taxane-based chemotherapy (NACT). NACT offers a window to profile pre-versus post-therapy tumor specimens, which we used to identify chemotherapy-induced changes to the tumor microenvironment. We hypothesized changes in the 免疫 microenvironment correlate with tumor chemo-response and 疾病 progression. We obtained matched pre- and post-NACT archival tumor tissues from patients with high-grade serous ovarian
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