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原文連結
論文資訊
- 類型：已發表論文
- 日期：2020-06-29
摘要
Oral mucositis (OM) is a common debilitating dose-limiting toxicity of 癌症 treatment, including hematopoietic stem cell transplantation (HSCT). We hypothesized that the oral microbiome is disturbed during allogeneic HSCT, partially accounting for the variability in OM severity. Using 16S ribosomal RNA gene sequence analysis, metabolomic profiling, and 計算 methods, we characterized the behavior of the salivary microbiome and metabolome of 184 patients pre- and post-HSCT. Transplantation was associated with a decrease in oral a 多樣性 in all patients. In contrast to the gut microbiome, an association with overall survival was not detected. Among 135 patients given methotrexate for graft-versus-host 疾病 prophylaxis pre-HSCT, Kingella and Atopobium abundance correlated with future development of sev
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