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原文連結
論文資訊
- 類型：已發表論文
- 日期：2020-07-04
摘要
The utility of intratumour heterogeneity as a prognostic biomarker is the subject of ongoing clinical investigation. However, the relationship between this marker and its clinical impact is mediated by an 演化ary process that is not well understood. Here, we employ a spatial 計算 model of tumour 演化 to assess when, why and how intratumour heterogeneity can be used to forecast tumour growth rate and progression-free survival. We identify three conditions that can lead to a positive correlation between clonal 多樣性 and subsequent growth rate: 多樣性 is measured early in tumour development; selective sweeps are rare; and/or tumours vary in the rate at which they acquire driver 突變s. Opposite conditions typically lead to negative correlation. In cohorts of tumours with diverse 演化ary parameters, we find t
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