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原文連結
論文資訊
- 類型：已發表論文
- 日期：2020-07-21
摘要
Opioid addiction is a chronic, relapsing disorder associated with persistent changes in 大腦 plasticity. Reconfiguration of neuronal connectivity may explain heightened abuse liability in individuals with a history of chronic drug exposure. To characterize 網絡-level changes in neuronal activity induced by chronic opiate exposure, we compared FOS expression in mice that are morphinenaive, morphine-dependent, or have undergone 4 wk of withdrawal from chronic morphine exposure, relative to saline-exposed controls. Pairwise interregional correlations in FOS expression data were used to construct 網絡 models that reveal a persistent reduction in connectivity strength following opiate dependence. Further, we demonstrate that basal gene expression patterns are predictive of changes in FOS correlation
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