本頁只刊出中文翻譯與中文說明；英文原文請見下方原文連結。
原文連結
論文資訊
- 類型：已發表論文
- 日期：2020-12-03
摘要
自然選擇 can promote or hinder a 族群's evolvability-the ability to evolve new and adaptive phenotypes-but the underlying mechanisms are poorly understood. To examine how the strength of selection affects evolvability, we subjected 族群s of yellow fluorescent 蛋白質 to directed 演化 under different selection regimes and then evolved them toward the new phenotype of green fluorescence. 族群s under strong selection for the yellow phenotype evolved the green phenotype most rapidly. They did so by accumulating 突變s that increase both robustness to 突變s and foldability. Under weak selection, neofunctionalizing 突變s rose to higher frequency at first, but more frequent deleterious 突變s undermined their eventual success. Our experiments show how selection can enhance evolvability by enhancing robustness and create t
※ 此為已發表論文，全文需透過期刊付費取得