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原文連結
論文資訊
- 類型：已發表論文
- 日期：2021-01-11
摘要
Because gene expression is important for 演化ary 適應, its misregulation is an important cause of mal適應. A misregulated gene can be incorrectly silent (“off”) when a transcription factor (TF) that is required for its activation does not binds its regulatory region. Conversely, a misregulated gene can be incorrectly active (“on”) when a TF not normally involved in its activation binds its regulatory region, a phenomenon also known as regulatory crosstalk. DNA 突變s that destroy or create TF binding sites on DNA are an important source of misregulation and crosstalk. Although misregulation reduces fitness in an environment to which an organism is well-adapted, it may become adaptive in a new environment. Here, I derive simple yet general 數學 expressions that delimit the conditions under which misre
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