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原文連結
論文資訊
- 類型：已發表論文
- 日期：2021-01-15
摘要
Whole 基因組 bisulfite sequencing is currently at the forefront of epi遺傳 analysis, facilitating the nucleotide-level resolution of 5-methylcytosine (5mC) on a 基因組-wide scale. Specialized software have been developed to accommodate the unique difficulties in aligning such sequencing reads to a given reference, building on the knowledge acquired from model organisms such as human, or Arabidopsis thaliana. As the field of epi遺傳s expands its purview to non-model plant 物種, new challenges arise which bring into question the suitability of previously established tools. Herein, nine short-read aligners are evaluated: Bismark, BS-Seeker2, BSMAP, BWA-meth, ERNE-BS5, GEM3, GSNAP, Last and segemehl. Precision-recall of simulated alignments, in comparison to real sequencing data obtained from three natura
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