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原文連結
論文資訊
- 類型：已發表論文
- 日期：2021-03-21
摘要
BACKGROUND: The psychosis spectrum (PS) is associated with structural dysconnectivity concentrated in trans modal cortex. However, understanding of this pathophysiology has been limited by an overreliance on examining direct interregional connectivity. Using 網絡 control theory, we measured variation in both direct and indirect connectivity to a region to gain new insights into the pathophysiology of the PS. METHODS: We used psychosis symptom data and structural connectivity in 1068 individuals from the Philadelphia Neurodevelopmental Cohort. Applying a 網絡 control theory metric called average controllability, we estimated each 大腦 region's capacity to leverage its direct and indirect structural connections to control linear 大腦 dynamics. Using 非線性 regression, we determined the accuracy with wh
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