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原文連結
論文資訊
- 類型：已發表論文
- 日期：2021-04-11
摘要
The 演化 of diverse phenotypes both involves and is constrained by molecular interaction 網絡s. When these 網絡s influence patterns of expression, we refer to them as gene regulatory 網絡s (GRNs). Here, we develop a 族群 遺傳 model of GRN 演化. With this model, we prove that–across a broad spectrum of viability and 突變 functions–the dynamics converge to a stationary distribution over GRNs. Next, we show from first principles how the frequency of GRNs at equilibrium will be proportional to each GRN’s eigenvector centrality in the genotype 網絡. Finally, we determine the structural characteristics of GRNs that are favored in response to a range of selective environments and 突變al constraints. Our work connects GRN 演化 to 族群 遺傳 models, and thus can provide a mechanistic explanation for the topology of GRNs expe
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