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原文連結
論文資訊
- 類型：已發表論文
- 日期：2021-05-03
摘要
Background and Aims In the CENTRAL trial context, we found diverse liver fat dynamics in response to different dietary interventions. Epi遺傳 mechanisms may contribute to the intraindividual variation. Moreover, 遺傳 factors are involved in developing nonalcoholic fatty-liver 疾病 (NAFLD), a 疾病 reflected by an increase in intrahepatic fat (IHF). In this exploratory analysis, we primarily aimed to examine the effect of lifestyle interventions on DNA-methylation of NAFLD related genes associated with IHF. Methods For 120 participants from the CENTRAL trial, an 18-month regimen of either low-fat (LF) or Mediterranean-low carbohydrate (MED/LC) diets, with or without physical activity (PA+/PA−), was instructed. Magnetic resonance imaging was used to measure IHF%, which was analysed for association wi
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