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論文資訊
- 類型：已發表論文
- 日期：2021-05-04
摘要
One key feature of 蛋白質s that form liquid droplets by phase separation inside a cell is the presence of multiple sites – multivalency – that mediate interactions with other 蛋白質s. We know little about the variation of multivalency on 演化ary time scales. Here, we investigated the long-term 演化 (∼600 million years) of multivalency in fungal mRNA decapping subunit 2 蛋白質 (Dcp2), and in the FET 蛋白質 family. We found that multivalency varies substantially among the orthologs of these 蛋白質s. However, 演化 has maintained the length scale at which sequence motifs that enable 蛋白質-蛋白質 interactions occur. That is, the total number of such motifs per hundred amino acids is higher and less variable than expected by neutral 演化. To help explain this 演化ary conservation, we developed a conformation classifier using
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