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原文連結
論文資訊
- 類型:已發表論文
- 日期:2021-05-26
摘要
Background Small 蛋白質s have received increasing attention in recent years. They have in particular been implicated as signals contributing to the coordination of 細菌l communities. In 基因組 annotations they are often missing or hidden among large numbers of hypothetical 蛋白質s because 基因組 annotation pipelines often exclude short open reading frames or over-predict hypothetical 蛋白質s based on simple models. The validation of novel 蛋白質s, and in particular of small 蛋白質s (s蛋白質s), therefore requires additional evidence. Proteogenomics is considered the gold standard for this purpose. It extends beyond established annotations and includes all possible open reading frames (ORFs) as potential sources of peptides, thus allowing the discovery of novel, unannotated 蛋白質s. Typically this results in large numbe
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