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原文連結
論文資訊
- 類型：已發表論文
- 日期：2021-05-26
摘要
In high-傳播 endemic regions, local 族群s of Plasmodium falciparum exhibit vast 多樣性 of the var genes encoding its major surface antigen, with each parasite comprising multiple copies from this diverse gene pool. This strategy to evade the 免疫 system through large combinatorial antigenic 多樣性 is common to other hyperdiverse pathogens. It underlies a series of fundamental 流行病學ological characteristics, including large reservoirs of 傳播 from high prevalence of asymptomatics and long-lasting infections. Previous theory has shown that negative frequency-dependent selection (NFDS) mediated by the acquisition of specific immunity by hosts structures the 多樣性 of var gene repertoires, or strains, in a pattern of limiting similarity that is both non-random and non-neutral. A combination of 隨機 智能體-based model
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