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原文連結
論文資訊
- 類型：已發表論文
- 日期：2021-06-09
摘要
Dynamical 大腦 state transitions are critical for flexible working memory but the 網絡 mechanisms are incompletely understood. Here, we show that working memory performance entails 大腦-wide switching between activity states using a combination of functional magnetic resonance imaging in healthy controls and individuals with schizophrenia, pharmacological fMRI, 遺傳 analyses and 網絡 control theory. The stability of states relates to dopamine D1 receptor gene expression while state transitions are influenced by D2 receptor expression and pharmacological modulation. Individuals with schizophrenia show altered 網絡 control properties, including a more diverse energy landscape and decreased stability of working memory representations. Our results demonstrate the relevance of dopamine signaling for the st
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