本頁只刊出中文翻譯與中文說明；英文原文請見下方原文連結。
原文連結
論文資訊
- 類型：已發表論文
- 日期：2021-06-09
摘要
Neuropathological staging studies have suggested that tau pathology spreads through the 大腦 in Alzheimer's 疾病 (AD) and other tauopathies, but it is unclear how neuroanatomical connections, spatial proximity, and regional vulnerability contribute. In this study, we seed tau pathology in the 大腦s of nontransgenic mice with AD tau and quantify pathology development over 9 months in 134 大腦 regions. 網絡 modeling of pathology progression shows that 擴散 through the connectome is the best predictor of tau pathology patterns. Further, deviations from pure neuroanatomical spread are used to estimate regional vulnerability to tau pathology and identify related gene expression patterns. Last, we show that pathology spread is altered in mice harboring a 突變 in leucine-rich repeat kinase 2. While tau patholo
※ 此為已發表論文，全文需透過期刊付費取得